Background

• Constipation due to clozapine is common and potentially life-threatening with an estimated prevalence
  of 31.2%.
• The FDA implemented a box warning about the risk of clozapine-induced constipation in early 2020 emphasizing the importance of bowel monitoring.
• Fulton State Hospital implemented a clozapine constipation protocol in 2017 to address
  clozapine-induced constipation.
• Starting in March 2020, hospital wards started to be quarantined to minimize the spread of COVID-19, which decreased the number of activities offered to clients and increased sedentary behaviors, potentially increasing cases of clozapine-induced constipation.

Objectives

To determine if COVID-19 quarantines impacted constipation due to clozapine by analyzing:

• The number of medical referrals for constipation
• Scheduled medication adherence for constipation
• PRN medications utilized for constipation
• Change in physical activity attendance
  

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