Background
- Current guidelines suggest reserving combination antipsychotic therapy (CAT) as a fourth- or fifth-line option in cases of resistance
- Previous studies investigating CAT have found an increase in movement-related adverse effects, although not significant, as well as predicted reduced survival rate while little significant clinical benefit has been seen
- There is limited prior evidence investigating risks of CAT in the forensic population
- Few previous studies have investigated patient outcomes in a pre-post design to mitigate limitations of varying severities of illness
Objectives
Primary Outcome
- Compare frequency of adverse drug reactions (ADRs) in patients before and after initiation of combination
antipsychotic therapy
Secondary Outcomes
- Evaluate frequency of medication use for extrapyramidal symptoms (EPS), hyperlipidemia (HLD), or diabetes in patients before and after initiation of multiple antipsychotics
- Assess changes in lipid profiles, A1C, complete blood count (CBC), and BMI
- Compare frequency of ADRs for each combination regimen
Read the Outcomes Study by submitting the form below.