---
title: Outcomes Study: Effectiveness Evaluation of the Combination of Liposomal Bupivacaine with Unencapsulated Bupivacaine Versus Unencapsulated Bupivacaine Alone in a Post-Operative Setting
description: "Read about our team's recent research: Effectiveness Evaluation of the Combination of Liposomal Bupivacaine with Unencapsulated Bupivacaine Versus Unencapsulated Bupivacaine Alone in a Post-Operative Setting."
---

[Perspectives ](https://perspectives.cps.com)

# [Outcomes Study: Effectiveness Evaluation of the Combination of Liposomal Bupivacaine with Unencapsulated Bupivacaine Versus Unencapsulated Bupivacaine Alone in a Post-Operative Setting](https://perspectives.cps.com/analgesia-effectiveness-bupivacaine)

 Written by [admin](https://perspectives.cps.com/author/admin) | Dec 5, 2023 8:58:15 PM

#### Background

- Liposomal Bupivacaine (Exparel) has been a common post-operative analgesic option since 2012
- Commonly used for bunionectomy, hemorrhoidectomy, and interscalene brachial plexus nerve block
- Current AWP = $515 per 20 mL vial
- Literature published in Anesthesiology in February 2021 by Ilfeld et al provided opposing evidence for the use of  
  liposomal bupivacaine
- Many hospital formulary committees have begun to limit the availability of liposomal bupivacaine or remove it from formulary
- In Fall 2021, FMC P&T Committee discussed possibility of limiting Exparel use
- FMC Surgeons want to see internal data before formulary alterations are made
- Most surgeons at FMC had previously used liposomal bupivacaine in combination with unencapsulated bupivacaine for post-operation analgesia
- Study assessed the post-operative pain and medication usage who receive: 
    - Liposomal bupivacaine + unencapsulated bupivacaine
      
      OR
    - Unencapsulated bupivacaine alone
- Results could drive formulary changes and ultimately cost savings

 

Read the Outcomes Study by submitting the form below.

**​**

[View full post](https://perspectives.cps.com/analgesia-effectiveness-bupivacaine)

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